Short answer: no. While there is mythology that goes along with this constellation, the twins and many other Western astrologers don’t consider Ophiuchus a sign.
“The zodiac that we use for modern ‘Tropical’ horoscopes is based on our view of the sky from the earth, divided into 12 pieces, and oriented by the four seasons,” the twins note. “While the individual zodiac signs are named after the constellations, their physical placement is not based on those actual constellations in our modern form of astrology. Understandably, this causes confusion for many people.”
And while yes, the constellations have shifted over the years, and some forms of astrology do acknowledge the shifting cosmos, Western astrology is fixed and isn’t changing based on shifting planets or constellations anytime soon.